|
Related Stories »
Latest Forex TV Video »
: Forest Labs, Gedeon Richter Report Positive Results From Phase IIb Study Of Schizophrenia Drug Cariprazine - Update (RTTNews) - Wednesday, Forest Laboratories, Inc. (FRX) and Gedeon Richter Plc said that data from a Phase IIb clinical trial of the investigational antipsychotic agent Cariprazine to treat acute schizophrenia showed positive results. For the primary endpoint, which is the Positive and Negative Syndrome Scale or PANSS, the data showed that schizophrenia patients treated with the drug experienced significant symptom improvement, compared with patients on placebo, within the first week of treatment and at each subsequent time point studied. "Both the latest clinical trial results for cariprazine in patients suffering from schizophrenia and the previous proof of concept results in bipolar mania, confirm our long held belief in this compound," said Howard Solomon, chairman and chief executive officer of Forest Laboratories. The placebo- and active-controlled, fixed dose study enrolled patients with acute exacerbation of schizophrenia. Patients who met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria for schizophrenia and had a PANSS total score between 80 and 120 were eligible for enrollment into the study. Based on the Phase 2b data, after a complete review of the full results, and the previously announced Phase 2 results in patients with acute mania associated with bipolar I disorder, the companies intend to initiate Phase 3 trials for both indications in early 2010. The drug is also currently undergoing Phase 2 clinical trials in patients with Bipolar Depressive Disorder and as adjunctive therapy in Major Depressive Disorder. Discovered by researchers at Gedeon Richter and licensed in the United States and Canada by Forest Laboratories in 2004, Cariprazine is an orally active D3/D2 partial agonist with preferential binding to D3 receptors. Additionally, the drug has a relatively low potency at other receptor sites, such as 5-HT2C, histamine H1, muscarinic, and adrenergic receptor sites, that have been associated with adverse events in some other drugs in the class. FRX is closed Wednesday's last trade on the New York Stock Exchange at $27.29, down $0.59 or 2.12%. |
Top Content » |
Contributor Login | Free e-mail Alerts | About Us | Contact | Advertise With Us |
| Rates | News | Video | Currency Focus | Resources |
| Forex Spot Rates | Top Forex TV Economic News | Most Recent ForexTV Video | Euro (EUR) | Global Economic Calendar |
| Cross Rates | Commodity News | Forex News | Japanese Yen (JPY) | Currency Converter |
| Equity Market News | Stocks & Bonds | Sterling (GBP) | Glossary | |
| Charts | World Market Previews | Education Video Series | Swiss Franc (CHF) | Currency Codes |
| Forex Charts | Forex Market Commentary | ProSticks Analysis | Canadian Dollar (CAD) | Global Statistic Resources |
| ProStick Charts | Technical Analysis | Australian Dollar (AUD) | CPI Avg. Price Calculator | |
| New Zealand Dollar (NZD) | CPI Inflation Calculator | |||
| Nordic (NOK) | CIA World Factbook | |||
| EMEA | Pivot Point Calculator | |||
 |
Content Sharing | |||
| RISK DISCLAIMER: By using this web site you agree to its terms and conditions. Before deciding to invest in foreign exchange you should carefully consider your investment objectives, level of experience, and risk appetite. The possibility exists that you could sustain a loss of some or all of your initial investment and therefore you should not invest money that you cannot afford to lose. You should be aware of all the risks associated with foreign exchange trading, and seek advice from an independent financial advisor if you have any doubts. Forex (or FX or off-exchange foreign currency futures and options) trading involves substantial risk of loss and is not suitable for every investor. The value of currencies may fluctuate and investors may lose all or more than their original investments. Risks also include, but are not limited to, the potential for changing political and/or economic conditions that may substantially affect the price and/or liquidity of a currency. The impact of seasonal and geopolitical events is already factored into market prices. The leveraged nature of FX trading means that any market movement will have an equally proportional effect on your deposited funds and such may work against you as well as for you. Past results are no indication of future performance. Information contained this web site is intended for informational purposes only and was obtained from sources believed to be reliable. Information is in no way guaranteed. No guarantee of any kind is implied or possible where projections of future conditions are attempted. | ||||
| Privacy Policy | Terms and Conditions | ||||